An EC 2.1.1.* (methyltransferases) inhibitor that interferes with the action of (S)-tetrahydroprotoberberine N-methyltransferase (EC 2.1.1.122).
ChEBI ID: 77115
| Member | Definition | Class |
|---|---|---|
| berberine | berberine | |
| ethylmaleimide | A member of the class of maleimides that is the N-ethyl derivative of maleimide. | N-ethylmaleimide |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 3,838 (38.36) | 18.7374 |
| 1990's | 1,711 (17.10) | 18.2507 |
| 2000's | 1,290 (12.89) | 29.6817 |
| 2010's | 2,093 (20.92) | 24.3611 |
| 2020's | 1,072 (10.72) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 105 (1.03%) | 5.53% |
| Reviews | 356 (3.48%) | 6.00% |
| Case Studies | 13 (0.13%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9,768 (95.37%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 29.3969 | 1 | 2 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 37.9330 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 177.8280 | 2 | 2 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 0.1995 | 1 | 1 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 6.5656 | 1 | 2 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| cytochrome P450 2D6 isoform 1 | Homo sapiens (human) | Potency | 2.5119 | 1 | 1 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 12.5893 | 2 | 2 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 29.8493 | 1 | 1 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 0.9733 | 1 | 2 |
| EWS/FLI fusion protein | Homo sapiens (human) | Potency | 8.3572 | 4 | 4 |
| Fumarate hydratase | Homo sapiens (human) | Potency | 33.1734 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 1 | 1 |
| geminin | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | Homo sapiens (human) | Potency | 2.5119 | 2 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 10.4304 | 2 | 2 |
| Interferon beta | Homo sapiens (human) | Potency | 10.4353 | 1 | 3 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 20.8954 | 2 | 2 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 7.0871 | 2 | 2 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 6.2426 | 2 | 2 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 42.5615 | 1 | 1 |
| polyprotein | Zika virus | Potency | 33.1734 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 10.4353 | 1 | 2 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 3.7686 | 1 | 1 |
| survival motor neuron protein isoform d | Homo sapiens (human) | Potency | 7.0795 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 10.6213 | 1 | 1 |
| Thrombopoietin | Homo sapiens (human) | Potency | 1.5849 | 2 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 12.5893 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| 14 kDa phosphohistidine phosphatase | Homo sapiens (human) | Ki | 209.0000 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 0.7827 | 3 | 3 |
| Acetylcholinesterase | Homo sapiens (human) | IC50 | 0.4000 | 2 | 2 |
| Aldo-keto reductase family 1 member C2 | Homo sapiens (human) | IC50 | 6.7100 | 1 | 1 |
| Aldo-keto reductase family 1 member C3 | Homo sapiens (human) | IC50 | 4.9900 | 2 | 2 |
| Cholinesterase | Equus caballus (horse) | IC50 | 15.2667 | 3 | 3 |
| Cholinesterase | Homo sapiens (human) | IC50 | 15.8950 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.9747 | 3 | 3 |
| Cytochrome P450 1B1 | Homo sapiens (human) | Ki | 0.0440 | 1 | 1 |
| Ghrelin O-acyltransferase | Homo sapiens (human) | IC50 | 433.0000 | 1 | 1 |
| Lysine-specific histone demethylase 1A | Homo sapiens (human) | IC50 | 6.9700 | 1 | 1 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 16.6000 | 1 | 1 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 35.3500 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | Ki | 14.3000 | 1 | 1 |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | IC50 | 66.0693 | 1 | 1 |
| Prolyl endopeptidase | Homo sapiens (human) | IC50 | 143.5000 | 2 | 2 |
| Telomerase reverse transcriptase | Homo sapiens (human) | IC50 | 37.0000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 67.0000 | 1 | 1 |